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20, S35S38

Rosiglitazone, an inhibitor of ACSL4, reduced the contents of MDA and iron in the kidneys of DN mice, thus increasing the survival rate and renal function of these mice [225]

On the other hand, cellular release of zinc in the brain can mediate neuronal apoptosis and may be pathologically associated with Alzheimers disease and amyotrophic lateral sclerosis (ALS) (80)

And phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) signal transduction pathways are also likely to regulate FASN expression (63, 64)